In this study, using an animal model of precocious puberty and a network pharmacology-based analysis, the female hormone-suppressing effect and treatment mechanism of Anemarrhanae Rhizoma and Phellodendri Cortex Extract was confirmed.In addition, as a result of analyzing the therapeutic mechanism of jasmine and yellow white through network pharmacology, it was found to be related to the gonadotropin-releasing hormone (GnRH) secreted by the pituitary gland and the ovarian steroid hormone production pathway.Through this, it can be seen that the mixed extract of jimo and yellow white is involved in the regulation of the hypothalamus-pituitary-gonadal axis, which is the central axis of sex hormone secretion.These research results were published in the SCI(E)-level international academic journal Plants.Newspaper business registration number: Seoul D07258 / Registration date: 2005.12.20./ Founding Date: 1967.12.30.Internet newspaper business registration number: Seoul A04023 / registration date: 2016.1.26./ Founding date: 2004.3.2.Title: Oriental Medicine Newspaper / Publisher: Hong Joo / Editor: Hwang Byung-cheon / Youth Protection Officer: Choi Seong-hoon Publisher (Address): 91 Heojun-ro, Gangseo-gu, Seoul (26-27 Gayang-dong) Korean Medical Association TEL: 02-2657-5080 FAX: 02-2657- 5004